Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1998 1
1999 1
2009 1
2010 1
2011 2
2012 4
2013 2
2014 2
2015 2
2016 2
2017 3
2018 5
2019 5
2020 14
2021 7
2022 11
2023 8
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

65 results

Results by year

Filters applied: . Clear all
Page 1
Did you mean fdg and lor (9 results)?
Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis.
Guttman-Yassky E, Bissonnette R, Ungar B, Suárez-Fariñas M, Ardeleanu M, Esaki H, Suprun M, Estrada Y, Xu H, Peng X, Silverberg JI, Menter A, Krueger JG, Zhang R, Chaudhry U, Swanson B, Graham NMH, Pirozzi G, Yancopoulos GD, D Hamilton JD. Guttman-Yassky E, et al. J Allergy Clin Immunol. 2019 Jan;143(1):155-172. doi: 10.1016/j.jaci.2018.08.022. Epub 2018 Sep 5. J Allergy Clin Immunol. 2019. PMID: 30194992 Free article. Clinical Trial.
Dupilumab significantly reduced expression of genes involved in type 2 inflammation (IL13, IL31, CCL17, CCL18, and CCL26), epidermal hyperplasia (keratin 16 [K16] and MKi67), T cells, dendritic cells (ICOS, CD11c, and CTLA4), and T(H)17/T(H)22 activity (IL17A, IL-22, and S100As) …
Dupilumab significantly reduced expression of genes involved in type 2 inflammation (IL13, IL31, CCL17, CCL18, and CCL26), epidermal hyperpl …
Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.
Furue M. Furue M. Int J Mol Sci. 2020 Jul 29;21(15):5382. doi: 10.3390/ijms21155382. Int J Mol Sci. 2020. PMID: 32751111 Free PMC article. Review.
The barrier dysfunction correlates with the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL). IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of …
The barrier dysfunction correlates with the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR …
PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes.
Tsuji G, Hashimoto-Hachiya A, Yumine A, Takemura M, Kido-Nakahara M, Ito T, Yamamura K, Nakahara T. Tsuji G, et al. J Dermatol Sci. 2023 May;110(2):61-68. doi: 10.1016/j.jdermsci.2023.04.007. Epub 2023 Apr 28. J Dermatol Sci. 2023. PMID: 37156706 Free article.
PDE4 inhibition increases transcriptional activity of cAMP-responsive element binding protein (CREB). Therefore, we hypothesized that difamilast may affect FLG and LOR expression via CREB in human keratinocytes. OBJECTIVE: To elucidate the mechanism by which difamil …
PDE4 inhibition increases transcriptional activity of cAMP-responsive element binding protein (CREB). Therefore, we hypothesized that difami …
Nuclear IL-33 Plays an Important Role in the Suppression of FLG, LOR, Keratin 1, and Keratin 10 by IL-4 and IL-13 in Human Keratinocytes.
Dai X, Utsunomiya R, Shiraishi K, Mori H, Muto J, Murakami M, Sayama K. Dai X, et al. J Invest Dermatol. 2021 Nov;141(11):2646-2655.e6. doi: 10.1016/j.jid.2021.04.002. Epub 2021 Apr 16. J Invest Dermatol. 2021. PMID: 33865911 Free article.
In monolayer culture and living skin equivalent analyses, IL-4 and IL-13 increased the expression of full-length IL-33 in the nucleus of keratinocytes by activating the MAPK/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase signaling pathway, whic …
In monolayer culture and living skin equivalent analyses, IL-4 and IL-13 increased the expression of full-length IL-33 in the nucleus of ker …
Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1.
Hashimoto-Hachiya A, Tsuji G, Murai M, Yan X, Furue M. Hashimoto-Hachiya A, et al. Int J Mol Sci. 2018 Jun 4;19(6):1654. doi: 10.3390/ijms19061654. Int J Mol Sci. 2018. PMID: 29866992 Free PMC article.
As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata …
As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier …
Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function.
Kim SH, Seong GS, Choung SY. Kim SH, et al. Nutrients. 2020 Jan 18;12(1):249. doi: 10.3390/nu12010249. Nutrients. 2020. PMID: 31963703 Free PMC article.
Furthermore, the expressions of the skin barrier-related proteins including filaggrin (FLG), loricrin (LOR), involucrin (IVL), zonula occludens-1 (ZO-1), and occludin (OCC) were restored by F.NONI treatment. ...
Furthermore, the expressions of the skin barrier-related proteins including filaggrin (FLG), loricrin (LOR), involucrin (IVL), …
Delayed type hypersensitivity reactions to various allergens may differently model inflammatory skin diseases.
Pavel AB, Del Duca E, Cheng J, Wu J, Ungar B, Estrada YD, Jack C, Maari C, Proulx ÉS, Ramirez-Valle F, Krueger JG, Bissonnette R, Guttman-Yassky E. Pavel AB, et al. Allergy. 2023 Jan;78(1):178-191. doi: 10.1111/all.15538. Epub 2022 Oct 8. Allergy. 2023. PMID: 36178084
Barrier defects that characterize both AD and psoriasis were best modeled by DPCP and Ni, followed by PPD, including downregulation of terminal differentiation (FLG, FLG2, LOR, LCEs), tight junction (CLDN1/CLDN8), and lipid metabolism (FA2H, FABP7)-related markers. …
Barrier defects that characterize both AD and psoriasis were best modeled by DPCP and Ni, followed by PPD, including downregulation of termi …
Screening and Research on Skin Barrier Damage Protective Efficacy of Different Mannosylerythritol Lipids.
Jing C, Guo J, Li Z, Xu X, Wang J, Zhai L, Liu J, Sun G, Wang F, Xu Y, Li Z, Zhao D, Jiang R, Sun L. Jing C, et al. Molecules. 2022 Jul 21;27(14):4648. doi: 10.3390/molecules27144648. Molecules. 2022. PMID: 35889520 Free PMC article.
Notably, MEL-B and MEL-C effectively protected HaCaT cells from UVB-induced damage by upregulating the contents of filaggrin (FLG) and transglutaminase-1 (TGM1), as determined via ELISA. Moreover, MEL-B treatment (20 mug/mL) of UVB-irradiated HaCaT cells led to the upregul …
Notably, MEL-B and MEL-C effectively protected HaCaT cells from UVB-induced damage by upregulating the contents of filaggrin (FLG) an …
Bifidobacterium longum and Galactooligosaccharide Improve Skin Barrier Dysfunction and Atopic Dermatitis-like Skin.
Kim S, Han SY, Lee J, Kim NR, Lee BR, Kim H, Kwon M, Ahn K, Noh Y, Kim SJ, Lee P, Kim D, Kim BE, Kim J. Kim S, et al. Allergy Asthma Immunol Res. 2022 Sep;14(5):549-564. doi: 10.4168/aair.2022.14.5.549. Allergy Asthma Immunol Res. 2022. PMID: 36174995 Free PMC article.
RESULTS: Fecal abundance of B. longum was negatively correlated with blood IL-13 expression in infants. B. longum or BLEVs increased expression of filaggrin (FLG) and loricrin (LOR) in HEKs. B. longum increased the efficacy of GOS to upregulate FLG and LOR …
RESULTS: Fecal abundance of B. longum was negatively correlated with blood IL-13 expression in infants. B. longum or BLEVs increased express …
The Effect and Mechanism of Burnet Gels on Steroid-Dependent Dermatitis in Guinea Pig Model.
Ma W, Ma X, Li X, Xi X, Mao C, Wang L. Ma W, et al. Biomed Res Int. 2022 Sep 13;2022:5866824. doi: 10.1155/2022/5866824. eCollection 2022. Biomed Res Int. 2022. PMID: 36147631 Free PMC article. Retracted.
The contents of IFN-gamma, IL-4, and IgE in the guinea pig serum were detected by the ELISA; the protein expression levels of FLG, LOR, and Caspase-14 in the epidermis of guinea pigs were detected by the immunohistochemical and Western blotting method. ...Compared w …
The contents of IFN-gamma, IL-4, and IgE in the guinea pig serum were detected by the ELISA; the protein expression levels of FLG, …
65 results